product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Drosophila melanogaster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr)
catalog :
MBS1120793
quantity :
1 mg (E Coli Derived
price :
3025 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1120793
products type :
Recombinant Protein
products full name :
Recombinant Drosophila melanogaster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr)
products short name :
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr)
products name syn :
Recombinant 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase EC= 1.1.1.34
other names :
HMG coenzyme A reductase, isoform C; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; CG10367 gene product from transcript CG10367-RA; 3-Hydroxy-3-Methylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; CG10367-PA; CG10367-PB; CG10367-PC; HMG coenzyme A reductase; HMG-CoA reductase; HMGCo-A reductase; HMGCoA reductase; Hmg-CoA-reductase; Hmgcr-PA; Hmgcr-PB; Hmgcr-PC; columbus; HMG Coenzyme A reductase
products gene name syn :
Hmgcr; HmG-CoAR; CG10367
other gene names :
Hmgcr; Hmgcr; BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; DmelCG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; hmgrc; l(3)01152; HmG-CoAR; HMG-CoA reductase
uniprot entry name :
HMDH_DROME
host :
E Coli or Yeast
sequence positions :
1-920
sequence length :
920
sequence :
MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDKNNT
LDASSGLGTATASAAAAGGSGSGAGSGASGTIPPSSMGG
SATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTA
VLYCYYQFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAII
KFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQ
AEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQR
LEVLCMFAVLSVLVNYVVFMTFYPACLSLIFDLSRSGVD
MSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGL
MAVHIYSRVAFSGSDYDAVDKTLTPTLSLNVSNNRTESG
EIADIIIKWLTMSADHIVISIVLIALVVKFICFDNRDPL
PDQLRQSGPVAIAAKASQTTPIDEEHVEQEKDTENSAAV
RTLLFTIEDQSSANASTQTDLLPLRHRLVGPIKPPRPVQ
ECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKI
ESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDY
RKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATT
EGALVASTNRGCKALSVRGVRSVVEDVGMTRAPCVRFPS
VARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIA
MDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFP
DMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAA
TLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAA
NMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYM
TCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPG
DNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNR
SSIAVNSANNPLNVTVSSCSTIS
purity :
>90%
form :
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Drosophila melanogaster (Fruit fly)
other info2 :
Storage Buffer: PBS pH 7.4, 50% glycerol
ncbi gi num :
281362379
ncbi acc num :
NP_001163703.1
ncbi gb acc num :
NM_001170232.1
uniprot acc num :
P14773
ncbi mol weight :
98,317 Da
ncbi pathways :
Cholesterol Biosynthesis Pathway 365818!!Metabolic Pathways 132021!!Metabolism Of Lipids And Lipoproteins Pathway 365783!!Terpenoid Backbone Biosynthesis Pathway 3058!!Terpenoid Backbone Biosynthesis Pathway 408
uniprot summary :
Function: Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Ref.4. Catalytic activity: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH. Enzyme regulation: The activity of HMG-CoA-reductase is suppressed by exogenous mevalonate. Ref.1. Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue specificity: Highly expressed in embryonic gonadal mesoderm, where expression is initially broad, and then becomes restricted to a segmental pattern at stage 11. Expression is then further restricted to a cluster of cells in each of parasegments 10, 11 and 12, corresponding to the developing gonadal mesoderm. Not expressed in pole cells. Ref.4. Sequence similarities: Belongs to the HMG-CoA reductase family.Contains 1 SSD (sterol-sensing) domain.
size :
1 mg (E Coli Derived)
price :
3025 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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