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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Geranylgeranyl transferase type-1 subunit beta (PGGT1B)
catalog :
MBS1105853
quantity :
0.5 mg (E-Coli)
price :
1145 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1105853
products type :
Recombinant Protein
products full name :
Recombinant Human Geranylgeranyl transferase type-1 subunit beta (PGGT1B)
products short name :
Geranylgeranyl transferase type-1 subunit beta (PGGT1B)
products name syn :
Geranylgeranyl transferase type-1 subunit beta; EC=2.5.1.59; Geranylgeranyl transferase type I subunit beta; GGTase-I-beta; Type I protein geranyl-geranyltransferase subunit beta
other names :
geranylgeranyl transferase type-1 subunit beta; Geranylgeranyl transferase type-1 subunit beta; geranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; geranylgeranyltransferase type I beta subunit; geranylgeranyl transferase type I subunit beta; type I protein geranyl-geranyltransferase subunit beta; protein geranylgeranyltransferase type I, beta subunit; Geranylgeranyl transferase type I subunit beta; GGTase-I-beta; Type I protein geranyl-geranyltransferase subunit beta
products gene name :
PGGT1B
other gene names :
PGGT1B; PGGT1B; BGGI; GGTI; GGTase-I-beta
uniprot entry name :
PGTB1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-377
sequence length :
377
sequence :
MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY LGIPFNPSKA PGTAHPYDSG HIAMTYTGLS CLVILGDDLS RVNKEACLAG LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAITYI RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT SERLLDLHQS WKTKDSKQCS ENVHIST
purity :
>90%
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
products description :
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.
ncbi gi num :
167860116
ncbi acc num :
NP_005014.2
ncbi gb acc num :
NM_005023.3
uniprot acc num :
P53609
ncbi mol weight :
33,830 Da
ncbi summary :
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
uniprot summary :
PGGT1B: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding. Belongs to the protein prenyltransferase subunit beta family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.5.1.59; Transferase. Chromosomal Location of Human Ortholog: 5q22.3. Molecular Function: protein geranylgeranyltransferase activity; isoprenoid binding; zinc ion binding; CAAX-protein geranylgeranyltransferase activity; drug binding; peptide binding. Biological Process: protein geranylgeranylation; negative regulation of nitric-oxide synthase biosynthetic process; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of cell cycle
size1 :
0.5 mg (E-Coli)
price1 :
1145 USD
size2 :
0.05 mg (Baculovirus)
price2 :
1145
size3 :
0.5 mg (Yeast)
price3 :
1375
size4 :
0.05 mg (Mammalian-Cell)
price4 :
1375
size5 :
1 mg (E-Coli)
price5 :
1825
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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