catalog number :
MBS1105740
products type :
Recombinant Protein
products full name :
Recombinant Macaca mulatta (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88)
products short name :
(Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88)
products name syn :
Recombinant (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88); Myeloid differentiation primary response protein MyD88
other names :
myeloid differentiation primary response protein MyD88; Myeloid differentiation primary response protein MyD88; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response protein 88
products gene name syn :
MYD88
other gene names :
MYD88; MYD88
uniprot entry name :
MYD88_MACMU
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-296
sequence :
MAAGGPGTEPAAPVSSTSSLPLAALNMRVRRRLSLFLNV
RTQVAADWTALAEEMDFEYLEIRQLETHADPTGRLLDAW
QGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYI
LKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGH
MPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSD
RDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECD
FQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITV
CDYTNPCTKSWFWTRLAKALSLP
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Macaca mulatta (Rhesus macaque)
ncbi acc num :
NP_001124153.1
ncbi gb acc num :
NM_001130681.1
ncbi mol weight :
33,354 Da
ncbi pathways :
African Trypanosomiasis Pathway (194389); African Trypanosomiasis Pathway (194323); Apoptosis Pathway (86730); Apoptosis Pathway (470); Chagas Disease (American Trypanosomiasis) Pathway (147811); Chagas Disease (American Trypanosomiasis) Pathway (147795); Herpes Simplex Infection Pathway (377876); Herpes Simplex Infection Pathway (377865); Influenza A Pathway (217176); Influenza A Pathway (217150)
uniprot summary :
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes . By similarity. Subunit structure: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL1RL1. Interacts with IL18R1. Interacts with BMX and IRF7 . By similarity. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist . By similarity. Interacts with FLII . By similarity. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding . By similarity. Interacts with IRF1 . By similarity. Subcellular location: Cytoplasm . By similarity. Domain: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK . By similarity. Sequence similarities: Contains 1 death domain.Contains 1 TIR domain.