protein

Recombinant Rat Transthyretin (Ttr)

MBS1093188

0.5 mg (E-Coli)

865 USD

Recombinant Protein

Recombinant Rat Transthyretin (Ttr)

Transthyretin (Ttr)

Transthyretin; Prealbumin; TBPA

transthyretin; Transthyretin; transthyretin; prealbumin, amyloidosis type I; transthyretin; Prealbumin; TBPA

Ttr

Ttr; Tt

Ttr; Ttr; Lr1; Tbpa; Tt

TTHY_RAT

E Coli or Yeast or Baculovirus or Mammalian Cell

21-147

127

GPGGAGESKC PLMVKVLDAV RGSPAVDVAV KVFKKTADGS WEPFASGKTA ESGELHGLTT DEKFTEGVYR VELDTKSYWK ALGISPFHEY AEVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Rattus norvegicus (Rat)

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

333033763

NP_036813.2

NM_012681.2

P02767

15,720 Da

Amyloids Pathway (828371); Disease Pathway (828366); Diseases Associated With Visual Transduction Pathway (828414); Extracellular Matrix Organization Pathway (828431); Non-integrin Membrane-ECM Interactions Pathway (828440); Retinoid Cycle Disease Events Pathway (828415); Retinoid Metabolism And Transport Pathway (828283); Signal Transduction Pathway (828062); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (828284); Visual Phototransduction Pathway (828282)

binds thyroxine (T4) and 3,5,3' triiodothyronine (T3); plays a role in thyroid hormone transport in serum [RGD, Feb 2006]

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted; Secreted, signal peptide. Cellular Component: extracellular space; protein complex. Molecular Function: identical protein binding; hormone binding; protein heterodimerization activity; hormone activity. Biological Process: retinol metabolic process; thyroid hormone metabolic process

0.5 mg (E-Coli)

865 USD

0.05 mg (Baculovirus)

865

0.5 mg (Yeast)

1090

0.05 mg (Mammalian-Cell)

1090

1 mg (E-Coli)

1255