ELISA/assay

Human Receptor I For The Fc Region of Immunoglobulin G ELISA Kit

MBS108716

96 Strip Wells

600 USD

ELISA Kit

Human Receptor I For The Fc Region of Immunoglobulin G ELISA Kit

Receptor I For The Fc Region of Immunoglobulin G

Fc receptor, IgG, high affinity I; High affinity immunoglobulin gamma Fc receptor I; high affinity immunoglobulin gamma Fc receptor I; fcRI; fc-gamma RI; igG Fc receptor I; IgG high affinity Fc receptor; Fc receptor, IgG, high affinity I; Fc-gamma RI

FcgammaRI

Fcgr1; Fcgr1; CD64; IGGHAFC; AI323638; AV092959; FcgammaRI; Fcg1; IgG Fc receptor I; FcRI

FCGR1_MOUSE

Human

404

Store all reagents at 2-8 degree C

182888429

AAI60240.1

P26151

44,888 Da

Adaptive Immune System Pathway 971210!!Antigen Processing-Cross Presentation Pathway 1001199!!Class I MHC Mediated Antigen Processing Presentation Pathway 1001196!!Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway 1001203!!Cytokine Signaling In Immune System Pathway 970814!!FCGR Activation Pathway 1001275!!Fc Gamma R-mediated Phagocytosis Pathway 114297!!Fc Gamma R-mediated Phagocytosis Pathway 106590!!Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway 1001274!!Hematopoietic Cell Lineage Pathway 83275

Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Ref.4 Ref.5. Subunit structure: Interacts with FCERG1; forms a functional signaling complex . By similarity. Interacts with FLNA; prevents FCGR1A degradation . By similarity. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN . By similarity. Subcellular location: Cell membrane; Single-pass type I membrane protein. Note: Stabilized at the cell membrane through interaction with FCER1G . By similarity. Tissue specificity: Macrophage-specific. Post-translational modification: N-glycosylated. Ref.3Phosphorylated on serine residues. Ref.3. Disruption phenotype: According to Ref.4, mice display altered endocytosis of monomeric IgG and impaired antibody-dependent killing of cells by macrophage. Antigen presentation is also affected and those mice develop only reduced inflammatory responses. An increased in IgG responses is also detected associated with an increased number of antibody-forming cells. Ref.5, also reported that a variety of IgG2a-immune complex-dependent immune functions like protection against bacterial infection were impaired. Ref.4 Ref.5. Sequence similarities: Belongs to the immunoglobulin superfamily. FCGR1 family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Caution: It is uncertain whether Met-1 or Met-10 is the initiator.

96 Strip Wells

600 USD