catalog number :
MBS1086836
products type :
Recombinant Protein
products full name :
Recombinant Human Monocarboxylate transporter 4 (SLC16A3)
products short name :
Monocarboxylate transporter 4 (SLC16A3)
products name syn :
Recombinant Monocarboxylate transporter 4 (SLC16A3); Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 3
other names :
monocarboxylate transporter 4; Monocarboxylate transporter 4; monocarboxylate transporter 4; monocarboxylate transporter 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4); Solute carrier family 16 member 3
products gene name syn :
SLC16A3; MCT4
other gene names :
SLC16A3; SLC16A3; MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4; MCT4; MCT 4
uniprot entry name :
MOT4_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
406-465
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Homo sapiens (Human)
ncbi acc num :
NP_001035887.1
ncbi gb acc num :
NM_001042422.2
ncbi mol weight :
49,469 Da
ncbi pathways :
Basigin Interactions Pathway (106065); Cell Surface Interactions At The Vascular Wall Pathway (106062); Hemostasis Pathway (106028); Proton-coupled Monocarboxylate Transport Pathway (161065); Pyruvate Metabolism Pathway (106205); Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway (106327); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)
ncbi summary :
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
uniprot summary :
SLC16A3: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 17q25. Cellular Component: nuclear membrane; membrane; integral to plasma membrane; plasma membrane; actin cytoskeleton. Molecular Function: monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity. Biological Process: cellular metabolic process; monocarboxylic acid transport; blood coagulation; pyruvate metabolic process; leukocyte migration; transmembrane transport