Mouse Troponin T Type 1, Slow Skeletal ELISA Kit | MyBioSource MBS108518 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Troponin T Type 1, Slow Skeletal ELISA Kit

catalog :

MBS108518

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS108518

products type :

ELISA Kit

products full name :

Mouse Troponin T Type 1, Slow Skeletal ELISA Kit

products short name :

[Troponin T Type 1, Slow Skeletal]

other names :

[troponin T, slow skeletal muscle isoform c; Troponin T, slow skeletal muscle; troponin T, slow skeletal muscle; troponin-T1, skeletal, slow; slow skeletal muscle troponin T; troponin T type 1 (skeletal, slow); Slow skeletal muscle troponin T]

products gene name :

[TNNT1]

other gene names :

[TNNT1; TNNT1; ANM; TNT; NEM5; STNT; TNTS; TNT; TnTs; sTnT]

uniprot entry name :

TNNT1_HUMAN

reactivity :

Mouse

sequence length :

251

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TNNT1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

187173292

ncbi acc num :

NP_001119605.1

ncbi gb acc num :

NM_001126133.2

uniprot acc num :

P13805

ncbi mol weight :

32,948 Da

ncbi pathways :

Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)

ncbi summary :

This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TNNT1: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNT1 are the cause of nemaline myopathy type 5 (NEM5); also known as Amish nemaline myopathy (ANM). A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 5 is a severe and progressive form common among Old Order Amish. Affected infants display tremors with hypotonia and mild contractures of the shoulders and hips. Proximal contractures progressively weaken and a pectus carinatum deformity develops before children die of respiratory insufficiency, usually in the second year. Belongs to the troponin T family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Contractile. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: troponin complex; cytosol. Molecular Function: troponin T binding; tropomyosin binding. Biological Process: skeletal muscle contraction; slow-twitch skeletal muscle fiber contraction; negative regulation of muscle contraction; muscle filament sliding. Disease: Nemaline Myopathy 5

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095