Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 ELISA Kit | MyBioSource MBS108332 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 ELISA Kit

catalog :

MBS108332

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS108332

products type :

ELISA Kit

products full name :

Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 ELISA Kit

products short name :

[Serine Palmitoyltransferase, Long Chain Base Subunit 3]

other names :

[serine palmitoyltransferase 3; Serine palmitoyltransferase 3; serine palmitoyltransferase 3; LCB 3; SPT 3; serine-palmitoyl-CoA transferase 3; long chain base biosynthesis protein 3; long chain base biosynthesis protein 2b; serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2); serine palmitoyltransferase, long chain base subunit 3; Long chain base biosynthesis protein 2b; LCB2b; Long chain base biosynthesis protein 3; LCB 3; Serine-palmitoyl-CoA transferase 3]

products gene name :

[SPTLC3]

other gene names :

[SPTLC3; SPTLC3; LCB3; SPT3; LCB2B; hLCB2b; SPTLC2L; C20orf38; dJ718P11; dJ718P11.1; C20orf38; SPTLC2L; LCB2b; LCB 3; SPT 3]

uniprot entry name :

SPTC3_HUMAN

reactivity :

Human

sequence length :

552

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPTLC3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

119220554

ncbi acc num :

NP_060797.2

ncbi gb acc num :

NM_018327.2

uniprot acc num :

Q9NUV7

ncbi mol weight :

62,049 Da

ncbi pathways :

Ceramide Biosynthesis Pathway (524496); Ceramide Biosynthesis Pathway (468287); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Sphingolipid Metabolism Pathway (760636); Sphingolipid De Novo Biosynthesis Pathway (530750); Sphingolipid Metabolism Pathway (82994); Sphingolipid Metabolism Pathway (119543); Sphingolipid Metabolism Pathway (369); Sphingosine Biosynthesis Pathway (524497)

ncbi summary :

The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

uniprot summary :

SPTLC3: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SSSPTB has the ability to use a broader range of acyl-CoAs without apparent preference. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase; EC 2.3.1.50. Chromosomal Location of Human Ortholog: 20p12.1. Cellular Component: endoplasmic reticulum membrane; integral to membrane. Molecular Function: serine C-palmitoyltransferase activity; pyridoxal phosphate binding. Biological Process: sphingoid biosynthetic process; sphingolipid metabolic process; sphingolipid biosynthetic process

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage