catalog number :
MBS1071633
products type :
Recombinant Protein
products full name :
Recombinant Epstein-Barr virus Envelope glycoprotein B (gB)
products short name :
Envelope glycoprotein B (gB)
products name syn :
Recombinant Envelope glycoprotein B (gB); Envelope glycoprotein B; gB; GP115 Glycoprotein GP110
other names :
Envelope glycoprotein B; Envelope glycoprotein B; GP115; Glycoprotein GP110
products gene name syn :
gB; BALF4
other gene names :
gB; gB
uniprot entry name :
GB_EBVG
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence :
QTPEQPAPPATTVQPTATRQQTSFPFRVCELSSHGDLFR
FSSDIQCPSFGTRENHTEGLLMVFKDNIIPYSFKVRSYT
KIVTNILIYNGWYADSVTNRHEEKFSVDSYETDQMDTIY
QCYNAVKMTKGLTRVYVDRDGVNITVNLKPTGGLANGVR
RYASQTELYDAPGWLIWTYRTRTTVNCLITDMMAKSNSP
FDFFVTTTGQTVEMSPFYDGKNKETFHERADSFHVRTNY
KIVDYDNRGTNPQGERRAFLKGTYTLSWKLENRTAYCPL
QHWQTFDSTIATETGKSIHFVTDEGTSSFVTNTTVGIEL
PDAFKCIEEQVNKTMHEKYEAVQDRYTKGQEAITYFITS
GGLLLAWLPLTPRSLATVKNLTELTTPTSSPSSPSPPAP
PAARGSTSAAVLRRRRRDAGNATTPVPPAAPGKSLGTLN
NPATVQIQFAYDSLRRQINRMLGDLARAWCLEQKRQNMV
LRELTKINPTTVMSSIYGKAVAAKRLGDVISVSQCVPVN
QTVTLRKSMRVPGSETMCYSRPLVSFSFINDTKTYEGQL
GTDNEIFLTKKMTEVCQATSQYYFQSGNEIHVYNDYHHF
KTIELDGIATLQTFISLNTSLIENIDFASLELYSRDEQR
ASNVFDLEGIFEYNFQAQNIAGLRKDLDNAVSNGRNQFV
DGLGELMDSLGSVGQSITNLVSTVGGLFSSLVSGFISFF
KNP
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
other info1 :
Species: Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
products description :
Envelope glycoprotein that forms spikes at the surface of virion envelope. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gp350/220 to its receptor, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress (By similarity).
ncbi pathways :
Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)
uniprot summary :
Function: Envelope glycoprotein that forms spikes at the surface of virion envelope. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gp350/220 to its receptor, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress . By similarity. Subunit structure: Homotrimer; disulfide-linked. Subcellular location: Virion membrane; Single-pass type I membrane protein . By similarity. Host cell membrane; Single-pass type I membrane protein . By similarity. Host endosome membrane; Single-pass type I membrane protein . By similarity. Host Golgi apparatus membrane; Single-pass type I membrane protein . By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) . By similarity. Post-translational modification: A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds . By similarity. Sequence similarities: Belongs to the herpesviridae glycoprotein B family.