Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) | MyBioSource MBS1070579 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

catalog :

MBS1070579

quantity :

0.5 mg (E-Coli)

price :

1420 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1070579

products type :

Recombinant Protein

products full name :

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

products short name :

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

products name syn :

A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; ADAMTS-4; EC=3.4.24.82; ADMP-1; Aggrecanase-1

other names :

A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; Aggrecanase-1

products gene name :

ADAMTS4

products gene name syn :

ADAMTS4; KIAA0688; UNQ769/PRO1563

other gene names :

ADAMTS4; ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4

uniprot entry name :

ATS4_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

213-837

sequence length :

625

sequence :

FASLSRFV ETLVVADDKM AAFHGAGLKR YLLTVMAAAA KAFKHPSIRN PVSLVVTRLV ILGSGEEGPQ VGPSAAQTLR SFCAWQRGLN TPEDSDPDHF DTAILFTRQD LCGVSTCDTL GMADVGTVCD PARSCAIVED DGLQSAFTAA HELGHVFNML HDNSKPCISL NGPLSTSRHV MAPVMAHVDP EEPWSPCSAR FITDFLDNGY GHCLLDKPEA PLHLPVTFPG KDYDADRQCQ LTFGPDSRHC PQLPPPCAAL WCSGHLNGHA MCQTKHSPWA DGTPCGPAQA CMGGRCLHMD QLQDFNIPQA GGWGPWGPWG DCSRTCGGGV QFSSRDCTRP VPRNGGKYCE GRRTRFRSCN TEDCPTGSAL TFREEQCAAY NHRTDLFKSF PGPMDWVPRY TGVAPQDQCK LTCQAQALGY YYVLEPRVVD GTPCSPDSSS VCVQGRCIHA GCDRIIGSKK KFDKCMVCGG DGSGCSKQSG SFRKFRYGYN NVVTIPAGAT HILVRQQGNP GHRSIYLALK LPDGSYALNG EYTLMPSPTD VVLPGAVSLR YSGATAASET LSGHGPLAQP LTLQVLVAGN PQDTRLRYSF FVPRPTPSTP RPTPQDWLHR RAQILEILRR RPWAGRK

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

157427675

ncbi acc num :

NP_005090.3

ncbi gb acc num :

NM_005099.4

uniprot acc num :

O75173

ncbi mol weight :

90,197 Da

ncbi pathways :

Endochondral Ossification Pathway (198812)

ncbi summary :

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

uniprot summary :

ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site. Protein type: EC 3.4.24.82; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Protease. Chromosomal Location of Human Ortholog: 1q21-q23. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: peptidase activity; protein binding; protease binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity. Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development

size1 :

0.5 mg (E-Coli)

price1 :

1420 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1420

size3 :

0.5 mg (Yeast)

price3 :

1650

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1650

size5 :

1 mg (E-Coli)

price5 :

2400

more info or order :

MyBioSource product webpage