product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Botulinum neurotoxin type A (botA)
catalog :
MBS1068389
quantity :
1 mg (E Coli Derived
price :
2860 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1068389
products type :
Recombinant Protein
products full name :
Recombinant Botulinum neurotoxin type A (botA)
products short name :
Botulinum neurotoxin type A (botA)
products name syn :
Recombinant Botulinum neurotoxin type A (botA); Botulinum neurotoxin type A; BoNT/A EC= 3.4.24.69; Bontoxilysin-A; BOTOX Cleaved into the following 2 chains: 1. Botulinum neurotoxin A light chain 2. Botulinum neurotoxin A heavy chain
other names :
Botulinum neurotoxin type A; Botulinum neurotoxin type A; Bontoxilysin-A
products gene name syn :
botA; atx, bna
other gene names :
botA; atx; bna; BoNT/A; BOTOX
uniprot entry name :
BXA1_CLOBO
host :
E Coli or Yeast
sequence positions :
449-1296
sequence length :
1296
sequence :
ALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNI
EAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIG
QLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSR
IALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFL
GWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNI
GNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALV
SYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKV
NTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKN
NINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNS
MIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLK
DKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTS
ILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQL
FNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNS
ISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIK
QRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYING
RLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYF
NLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPY
YMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYL
NSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNK
EYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKND
QGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWY
NRQIERSSRTLGCSWEFIPVDDGWGERPL
purity :
>90%
form :
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Clostridium botulinum
other info2 :
Storage Buffer: PBS pH 7.4, 50% glycerol
ncbi gi num :
399133
ncbi acc num :
P10845.4
uniprot acc num :
P10845
ncbi mol weight :
149,454 Da
ncbi pathways :
Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!Salmonella Infection Pathway 375172!!Salmonella Infection Pathway 375149
uniprot summary :
Function: Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln- -Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure. Catalytic activity: Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates. Cofactor: Binds 1 zinc ion per subunit. Subunit structure: Disulfide-linked heterodimer of a light chain (L) and a heavy chain (H). Subcellular location: Botulinum neurotoxin A light chain: Secreted. Host cytoplasm host cytosol. Botulinum neurotoxin A heavy chain: Secreted. Host cell junction host synapse host presynaptic cell membrane; Multi-pass membrane protein . Potential. Pharmaceutical use: Available under the name BOTOX (Allergan) for the treatment of strabismus and blepharospasm associated with dystonia and cervical dystonia. Also used for the treatment of hemifacial spasm and a number of other neurological disorders characterized by abnormal muscle contraction. Miscellaneous: There are seven antigenically distinct forms of botulinum neurotoxin: Types A, B, C1, D, E, F, and G. Sequence similarities: Belongs to the peptidase M27 family.
size :
1 mg (E Coli Derived)
price :
2860 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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