catalog number :
MBS1065589
products type :
Recombinant Protein
products full name :
Recombinant Human Dynactin subunit 3 (DCTN3)
products short name :
Dynactin subunit 3 (DCTN3)
other names :
dynactin subunit 3 isoform 3; Dynactin subunit 3; dynactin subunit 3; dynactin light chain; dynactin complex subunit 22 kDa subunit; dynactin 3 (p22); Dynactin complex subunit 22 kDa subunit; p22
products gene name :
DCTN3
other gene names :
DCTN3; DCTN3; DCTN22; DCTN-22; p22
uniprot entry name :
DCTN3_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
2-186
sequence :
AGLTDLQRL QARVEELERW VYGPGGARGS RKVADGLVKV QVALGNISSK RERVKILYKK IEDLIKYLDP EYIDRIAIPD ASKLQFILAE EQFILSQVAL LEQVNALVPM LDSAHIKAVP EHAARLQRLA QIHIQQQDQC VEITEESKAL LEEYNKTTML LSKQFVQWDE LLCQLEAATQ VKPAEE
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)
other info2 :
Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ncbi acc num :
NP_001268354.1
ncbi gb acc num :
NM_001281425.1
ncbi mol weight :
18,001 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Centrosome Maturation Pathway 105807!!G2/M Transition Pathway 105801!!Immune System Pathway 106386!!Loss Of Nlp From Mitotic Centrosomes Pathway 105811!!Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway 105810!!MHC Class II Antigen Presentation Pathway 645290!!Mitotic G2-G2/M Phases Pathway 160942
ncbi summary :
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
size :
1 mg (E Coli Derived)