Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | MyBioSource MBS1041064 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 2-5A-dependent ribonuclease (RNASEL)

catalog :

MBS1041064

quantity :

0.5 mg (E-Coli)

price :

1555 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1041064

products type :

Recombinant Protein

products full name :

Recombinant Human 2-5A-dependent ribonuclease (RNASEL)

products short name :

2-5A-dependent ribonuclease (RNASEL)

products name syn :

2-5A-dependent ribonuclease; 2-5A-dependent RNase; EC=3.1.26.-; Ribonuclease 4; Ribonuclease L; RNase L

other names :

2-5A-dependent ribonuclease; 2-5A-dependent ribonuclease; 2-5A-dependent ribonuclease; RNase L; ribonuclease 4; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; 2',5'-oligoisoadenylate synthetase-dependent; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); Ribonuclease 4; Ribonuclease L; RNase L

products gene name :

RNASEL

products gene name syn :

RNASEL; RNS4

other gene names :

RNASEL; RNASEL; RNS4; PRCA1; RNS4; 2-5A-dependent RNase; RNase L

uniprot entry name :

RN5A_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-741

sequence length :

741

sequence :

MESRDHNNPQ EGPTSSSGRR AAVEDNHLLI KAVQNEDVDL VQQLLEGGAN VNFQEEEGGW TPLHNAVQMS REDIVELLLR HGADPVLRKK NGATPFILAA IAGSVKLLKL FLSKGADVNE CDFYGFTAFM EAAVYGKVKA LKFLYKRGAN VNLRRKTKED QERLRKGGAT ALMDAAEKGH VEVLKILLDE MGADVNACDN MGRNALIHAL LSSDDSDVEA ITHLLLDHGA DVNVRGERGK TPLILAVEKK HLGLVQRLLE QEHIEINDTD SDGKTALLLA VELKLKKIAE LLCKRGASTD CGDLVMTARR NYDHSLVKVL LSHGAKEDFH PPAEDWKPQS SHWGAALKDL HRIYRPMIGK LKFFIDEKYK IADTSEGGIY LGFYEKQEVA VKTFCEGSPR AQREVSCLQS SRENSHLVTF YGSESHRGHL FVCVTLCEQT LEACLDVHRG EDVENEEDEF ARNVLSSIFK AVQELHLSCG YTHQDLQPQN ILIDSKKAAH LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE DLKAQSNEEV VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK RGNFYQNTVG DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH SPNKPQCDGA GGASGLASPG C

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

ncbi gi num :

10863929

ncbi acc num :

NP_066956.1

ncbi gb acc num :

NM_021133.3

uniprot acc num :

Q05823

ncbi mol weight :

83,533 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Immune System Pathway (106386); Influenza A Pathway (217173); Influenza A Pathway (217150); Interferon Signaling Pathway (187103); Interferon Alpha/beta Signaling Pathway (187104)

ncbi summary :

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

uniprot summary :

RNASEL: a multifunctional enzyme that possesses protein kinase and endoribonuclease activity, Mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Ribonuclease; EC 3.1.26.-; Protein kinase, Other; Other group; Other-Unique family. Chromosomal Location of Human Ortholog: 1q25. Cellular Component: nuclear matrix; mitochondrion; cytosol. Molecular Function: endoribonuclease activity; rRNA binding; protein binding; RNA binding; metal ion binding; ATP binding; protein kinase activity. Biological Process: negative regulation of viral genome replication; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; mRNA processing; defense response to virus; protein amino acid phosphorylation; rRNA processing. Disease: Prostate Cancer, Hereditary, 1

size1 :

0.5 mg (E-Coli)

price1 :

1555 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1555

size3 :

0.5 mg (Yeast)

price3 :

1780

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1780

size5 :

1 mg (E-Coli)

price5 :

2670

more info or order :

MyBioSource product webpage