Recombinant Human Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1), partial | MyBioSource MBS1036425 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1), partial

catalog :

MBS1036425

quantity :

0.5 mg (E-Coli)

price :

1300 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1036425

products type :

Recombinant Protein

products full name :

Recombinant Human Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1), partial

products short name :

Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1), partial

products name syn :

Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a; Including the following 2 domains:; Serine/threonine-protein kinase; EC=2.7.11.1; Endoribonucleas

other names :

serine/threonine-protein kinase/endoribonuclease IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE1; ire1-alpha; inositol-requiring 1; ER to nucleus signalling 1; inositol-requiring enzyme 1; inositol-requiring protein 1; endoplasmic reticulum-to-nucleus signaling 1; endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

products gene name :

ERN1

products gene name syn :

ERN1; IRE1

other gene names :

ERN1; ERN1; IRE1; IRE1P; IRE1a; hIRE1p; hIRE1p; IRE1a

uniprot entry name :

ERN1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

153946421

ncbi acc num :

NP_001424.3

ncbi gb acc num :

NM_001433.3

uniprot acc num :

O75460

ncbi mol weight :

6,649 Da

ncbi pathways :

Activation Of Chaperones By IRE1alpha Pathway (105906); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Metabolism Of Proteins Pathway (106230); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Unfolded Protein Response Pathway (105904)

ncbi summary :

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

uniprot summary :

IRE1: a ser/thr protein kinase that possess endonuclease activity. Important in altering gene expression as a response to endoplasmic reticulum based stress signals. Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain, which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. Ubiquitously expressed. High levels observed in pancreatic tissue. Functionally connected with insulin biosynthesis in pancreatic beta cells. Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of IRE1. Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Chaperone; Ribonuclease; Endoplasmic reticulum; Apoptosis; Other group; IRE family. Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; cytoplasm; nuclear inner membrane; integral to endoplasmic reticulum membrane. Molecular Function: endoribonuclease activity; identical protein binding; protein serine/threonine kinase activity; protein binding; enzyme binding; protein homodimerization activity; magnesium ion binding; ADP binding; ATP binding. Biological Process: transcription, DNA-dependent; unfolded protein response; RNA splicing; protein amino acid autophosphorylation; protein amino acid phosphorylation; positive regulation of RNA splicing; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; endothelial cell proliferation; UFP-specific transcription factor mRNA processing during unfolded protein response; mRNA catabolic process; cell cycle arrest; regulation of macroautophagy; mRNA cleavage

size1 :

0.5 mg (E-Coli)

price1 :

1300 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1300

size3 :

0.5 mg (Yeast)

price3 :

1520

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1520

size5 :

1 mg (E-Coli)

price5 :

2110

more info or order :

MyBioSource product webpage