catalog number :
MBS1031087
products type :
Recombinant Protein
products full name :
Recombinant Mouse Serine protease inhibitor Kazal-type 3
products short name :
Serine protease inhibitor Kazal-type 3
products name syn :
P12; Prostatic secretory glycoprotein
other names :
serine protease inhibitor Kazal-type 1; Serine protease inhibitor Kazal-type 1; serine protease inhibitor Kazal-type 1; serine peptidase inhibitor, Kazal type 1; P12
products gene name :
Spink3
other gene names :
Spink1; Spink1; p12; Spink3
uniprot entry name :
ISK1_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
24-80
sequence :
AKVTGKEASCHDAVAGCPRIYDPVCGTDGITYANECVLC
FENRKRIEPVLIRKGGPC
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products description :
Serine protease inhibitor which exhibits anti-trypsin activity. Inhibits the uptake of calcium by spermatozoa.
products references :
A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas.Mills J.S., Needham M., Parker M.G.EMBO J. 6:3711-3717(1987)
Purification and characterization of a trypsin inhibitor from mouse seminal vesicle secretion.Lai M.-L., Chen S.-W., Chen Y.-H.Arch. Biochem. Biophys. 290:265-271(1991)
Developmental profile of a caltrin-like protease inhibitor, P12, in mouse seminal vesicle and characterization of its binding sites on sperm surface.Chen L.-Y., Lin Y.-H., Lai M.-L., Chen Y.-H.Biol. Reprod. 59:1498-1505(1998)
ncbi acc num :
NP_033284.1
ncbi gb acc num :
NM_009258.5
uniprot summary :
Spink3: Serine protease inhibitor which exhibits anti-trypsin activity. Inhibits the uptake of calcium by spermatozoa. By androgens in adult male sex accessory glands but expressed constitutively in pancreas. Protein type: Inhibitor. Cellular Component: acrosome; extracellular region; extracellular space. Molecular Function: protease inhibitor activity; serine-type endopeptidase inhibitor activity. Biological Process: negative regulation of peptidase activity; negative regulation of peptidyl-tyrosine phosphorylation; regulation of acrosome reaction