protein

Recombinant Macaca mulatta (Rhesus macaque) Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

MBS1018397

1 mg (E-Coli)

1375 USD

Recombinant Protein

Recombinant Macaca mulatta (Rhesus macaque) Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

(Rhesus macaque) Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1; slo1; maxiK; KCa1.1; slo-alpha; BK channel; BKCA alpha; k(VCA)alpha; slo homolog; maxi K channel; slowpoke homolog; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel, subfamily M subunit alpha-1; large conductance calcium-activated potassium channel subfamily M alpha member 1; BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog

Recombinant (Rhesus macaque) Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial; Calcium-activated potassium channel subunit alpha-1; BK channel BKCA alpha Calcium-activated potassium channel, subfamily M subunit alpha-1 K(VCA)alpha KCa1.1 Maxi K channel; MaxiK Slo-alpha Slo1 Slowpoke homolog; Slo homolog

KCNMA1; KCNMA1; KCNMA; MaxiK; Slo homolog

KCMA1_MACMU

E Coli or Yeast or Baculovirus or Mammalian Cell

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Macaca mulatta (Rhesus macaque)

KCNMA1; KCNMA

74136181

NP_001027982.1

NM_001032810.1

O18867

128,934 Da

Pancreatic Secretion Pathway (169308); Pancreatic Secretion Pathway (169295); Salivary Secretion Pathway (153378); Salivary Secretion Pathway (153352); Vascular Smooth Muscle Contraction Pathway (96532); Vascular Smooth Muscle Contraction Pathway (96866)

Function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) . By similarity. Enzyme regulation: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation . By similarity. Subunit structure: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity . By similarity. Subcellular location: Membrane; Multi-pass membrane protein . By similarity. Domain: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4 . By similarity.The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor . By similarity.The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium . By similarity.The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca2+ and Mg2+ . By similarity.The calcium bowl constitutes one of the Ca2+ sensors and probably acts as a Ca2+-binding site. There are however other Ca2+ sensors regions required for activation of the channel . By similarity.The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation . By similarity. Post-translational modification: Phosphorylated . Probable. Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity . By similarity. Miscellaneous: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca2+ and Mg2+. Sequence similarities: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. [View classification]Contains 1 RCK N-terminal domain.

1 mg (E-Coli)

1375 USD

1 mg (Yeast)

1835