Recombinant Mouse Heterogeneous nuclear ribonucleoproteins A2/B1 (Hnrnpa2b1) | MyBioSource MBS1017422 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Heterogeneous nuclear ribonucleoproteins A2/B1 (Hnrnpa2b1)

catalog :

MBS1017422

quantity :

0.01 mg (E-Coli)

price :

200 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS1017422

products type :

Recombinant Protein

products full name :

Recombinant Mouse Heterogeneous nuclear ribonucleoproteins A2/B1 (Hnrnpa2b1)

products short name :

[Heterogeneous nuclear ribonucleoproteins A2/B1 (Hnrnpa2b1)]

products name syn :

[Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1]

other names :

[heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1; Heterogeneous nuclear ribonucleoproteins A2/B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1; heterogenous nuclear ribonucleoprotein A2/B1; heterogeneous nuclear ribonucleoprotein A2/B1]

products gene name :

[Hnrnpa2b1]

products gene name syn :

[Hnrnpa2b1; Hnrpa2b1]

other gene names :

[Hnrnpa2b1; Hnrnpa2b1; Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik; Hnrpa2b1; hnRNP A2/B1]

uniprot entry name :

ROA2_MOUSE

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

[1-353. Full Length]

sequence :

MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRN
YYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAA
MAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVG
GIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFG
FVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQE
VQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGY
GSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGG
PGYGNQGGGYGGGYDNYGGGNYGSGSYNDFGNYNQQPSN
YGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRS
RY

purity :

>=90%

form :

Liquid containing glycerol

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

image1 heading :

SDS-PAGE

other info1 :

Species: Mus musculus (Mouse)

products description :

Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs

ncbi gi num :

109134362

ncbi acc num :

NP_058086.2

ncbi gb acc num :

NM_016806.3

uniprot acc num :

O88569

ncbi mol weight :

32,460 Da

ncbi pathways :

Gene Expression Pathway (971427); Processing Of Capped Intron-Containing Pre-mRNA Pathway (970809); MRNA Splicing Pathway (970580); MRNA Splicing - Major Pathway (971356); MRNA Processing Pathway (198369)

uniprot summary :

hnRNP A2/B1: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. 2 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; Spliceosome; RNA splicing. Cellular Component: spliceosome; neuron projection; membrane; cell soma; cytoplasm; perikaryon; chromatin; ribonucleoprotein complex; nucleus. Molecular Function: nucleic acid binding; single-stranded telomeric DNA binding; RNA binding; nucleotide binding. Biological Process: negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; negative regulation of transcription from RNA polymerase II promoter; mRNA processing; RNA transport

size1 :

0.01 mg (E-Coli)

price1 :

200 USD

size2 :

0.05 mg (E-Coli)

price2 :

260

size3 :

0.1 mg (E-Coli)

price3 :

430

size4 :

0.2 mg (E-Coli)

price4 :

685

size5 :

0.05 mg (Yeast)

price5 :

880

size6 :

0.05 mg (Baculovirus)

price6 :

1090

size7 :

0.5 mg (E-Coli)

price7 :

1125

size8 :

0.2 mg (Yeast)

price8 :

1180

size9 :

0.05 mg (Mammalian-Cell)

price9 :

1330

size10 :

0.5 mg (Yeast)

price10 :

1335

size11 :

0.1 mg (Baculovirus)

price11 :

1575

size12 :

1 mg (E-Coli)

price12 :

1725

size13 :

0.5 mg (Baculovirus)

price13 :

2050

size14 :

1 mg (Yeast)

price14 :

2110

size15 :

0.1 mg (Mammalian-Cell)

price15 :

2160

size16 :

1 mg (Baculovirus)

price16 :

3170

more info or order :

MyBioSource product webpage