catalog number :
MBS1013668
products type :
Recombinant Protein
products full name :
Recombinant Varicella-zoster virus Envelope glycoprotein H (gH)
products short name :
Envelope glycoprotein H (gH)
products name syn :
Recombinant Envelope glycoprotein H (gH); Envelope glycoprotein H; gH; Glycoprotein III; GPIII
other names :
Envelope glycoprotein H; Envelope glycoprotein H; Glycoprotein III
products gene name syn :
gH; ORF37
other gene names :
gH; gH; GPIII
uniprot entry name :
GH_VZVD
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
18-212
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
ncbi mol weight :
93,652 Da
ncbi pathways :
Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)
uniprot summary :
Function: The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis . By similarity. Subunit structure: Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. Associates with the gB-gH/gL-gD complex. Interacts with VP16 . By similarity. Subcellular location: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where final envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Ref.2. Sequence similarities: Belongs to the herpesviridae glycoprotein H family.