catalog number :
MBS1009704
products type :
Recombinant Protein
products full name :
Recombinant Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) Protein X
products short name :
Hepatitis B virus genotype D subtype ayw
products name syn :
HBx; Peptide X; pX
other names :
Protein X; Protein X; HBx; Peptide X; pX
uniprot entry name :
X_HBVD3
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-154
sequence :
MAARLCCQLDPARDVLCLRPVGAESRGRPFSGSLGTLSS
PSPSAVPTDHGAHLSLRGLPVCAFSSAGPCALRFTSARR
METTVNAHQILPKVLHKRTLGLSAMSTTDLEAYFKDCLF
KDWEELGEEIRLKVFVLGGCRHKLVCAPAPCNFFTSA
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D)
products description :
Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1.
products references :
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli."
Galibert F., Mandart E., Fitoussi F., Tiollais P., Charnay P.
Nature 281:646-650(1979)
ncbi mol weight :
16,618 Da
size5 :
0.05 mg (Baculovirus)