product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Shigella flexneri Invasin ipaB (ipaB), partial
catalog :
MBS1006202
quantity :
0.05 mg (E-Coli)
price :
720 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1006202
products type :
Recombinant Protein
products full name :
Recombinant Shigella flexneri Invasin ipaB (ipaB), partial
products short name :
[Invasin ipaB (ipaB)]
products name syn :
[Recombinant Invasin ipaB (ipaB); Invasin ipaB; 62 kDa antigen]
other names :
[invasion protein; Invasin IpaB; invasion protein; 62 kDa antigen]
products gene name syn :
[ipaB]
other gene names :
[ipaB; ipaB; S0136]
uniprot entry name :
IPAB_SHIFL
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[1-312. Partial]
sequence :
MHNVSTTTTGFPLAKILTSTELGDNTIQAANDAANKLFS
LTIADLTANQNINTTNAHSTSNILIPELKAPKSLNASSQ
LTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNL
EFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLEN
KINQIQTRLSELDPESPEKKKLSREEIQLTIKKDAAVKD
RTLIEQKTLSIHSKLTDKSMQLEKEIDSFSAFSNTASAE
QLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLA
LFQSLQESRKTEMERKSDEYAAEVRKAEELNRVMGCVGK
purity :
>=90%
form :
Liquid containing glycerol
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Shigella flexneri
ncbi gi num :
13449074
ncbi acc num :
NP_085290.1
ncbi gb acc num :
NC_002698.1
uniprot acc num :
P18011
ncbi mol weight :
62,201 Da
uniprot summary :
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell contact. This pore probably allows the translocation of IpaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important, along with IpaD, to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal, respectively. Through interaction with host human MAD2L2, constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization. Ref.7 Ref.9. Subunit structure: Interacts with host human MAD2L2; in the G2/M phase of the cell cycle. Ref.9. Subcellular location: Secreted. Host cell membrane; Multi-pass membrane protein . Potential. Host nucleus . Probable. Note: Secreted through the specialized type-III secretion system Mxi/Spa. Inserted into the host cell membrane. Also secreted into the host cell cytoplasm after the escape of bacteria from phagosome, where it colocalizes with ICE. May localize to host cell nucleus during G2/M phase of the host cell cycle. Ref.9. Induction: Synthesis of this immunogen is repressed at 30 degrees Celsius and restored at 37 degrees Celsius. Sequence similarities: Belongs to the invasin protein B family.
size1 :
0.05 mg (E-Coli)
price1 :
720 USD
size2 :
0.05 mg (Yeast)
price2 :
845
size3 :
0.2 mg (E-Coli)
price3 :
965
size4 :
0.05 mg (Baculovirus)
price4 :
1055
size5 :
0.5 mg (E-Coli)
price5 :
1060
size6 :
0.2 mg (Yeast)
price6 :
1135
size7 :
0.5 mg (Yeast)
price7 :
1280
size8 :
0.05 mg (Mammalian-Cell)
price8 :
1295
size9 :
0.1 mg (Baculovirus)
price9 :
1525
size10 :
1 mg (E-Coli)
price10 :
1600
size11 :
0.5 mg (Baculovirus)
price11 :
1990
size12 :
1 mg (Yeast)
price12 :
2025
size13 :
0.1 mg (Mammalian-Cell)
price13 :
2105
size14 :
1 mg (Baculovirus)
price14 :
3080
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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