Human Nuclear Receptor Related Protein 1 ELISA Kit | MyBioSource MBS100253 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Nuclear Receptor Related Protein 1 ELISA Kit

catalog :

MBS100253

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS100253

products type :

ELISA Kit

products full name :

Human Nuclear Receptor Related Protein 1 ELISA Kit

products short name :

[Nuclear Receptor Related Protein 1]

other names :

[nuclear receptor subfamily 4 group A member 1 isoform 1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4 group A member 1; ST-59; hormone receptor; TR3 orphan receptor; steroid receptor TR3; testicular receptor 3; early response protein NAK1; orphan nuclear receptor HMR; orphan nuclear receptor TR3; nuclear hormone receptor NUR/77; growth factor-inducible nuclear protein N10; nerve growth factor IB nuclear receptor variant 1; nuclear receptor subfamily 4, group A, member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3]

products gene name :

[NURR1]

other gene names :

[NR4A1; NR4A1; HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77; GFRP1; HMR; NAK1; Nur77]

uniprot entry name :

NR4A1_HUMAN

reactivity :

Human

sequence length :

598

storage stability :

Store all reagents at 2-8 degree C

ncbi gi num :

27894344

ncbi acc num :

NP_775180.1

ncbi gb acc num :

NM_173157.2

uniprot acc num :

P22736

ncbi mol weight :

64,463 Da

ncbi pathways :

AKT Phosphorylates Targets In The Nucleus Pathway (106476); Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); Corticotropin-releasing Hormone Pathway (920957); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR Pathway (160957)

ncbi summary :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Nur77: an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5 -AAAAGGTCA-3 . May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Protein type: Nuclear receptor; Apoptosis; DNA-binding. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleus. Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity. Biological Process: epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; fibroblast growth factor receptor signaling pathway; intracellular receptor-mediated signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; signal transduction; cell migration during sprouting angiogenesis; innate immune response; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of endothelial cell proliferation

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095