Recombinant Human Bile salt-activated lipase (CEL) | MyBioSource MBS1000851 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Bile salt-activated lipase (CEL)

catalog :

MBS1000851

quantity :

0.5 mg (E-Coli)

price :

1545 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1000851

products type :

Recombinant Protein

products full name :

Recombinant Human Bile salt-activated lipase (CEL)

products short name :

Bile salt-activated lipase (CEL)

products name syn :

Bile salt-activated lipase; BAL; EC=3.1.1.13; EC=3.1.1.3; Bile salt-stimulated lipase; BSSL; Bucelipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase

other names :

Bile salt-activated lipase; Bile salt-activated lipase; bile salt-activated lipase; bucelipase; sterol esterase; cholesterol esterase; carboxyl ester hydrolase; fetoacinar pancreatic protein; lysophospholipase, pancreatic; bile salt-dependent lipase, oncofetal isoform; carboxyl ester lipase (bile salt-stimulated lipase); carboxyl ester lipase; Bile salt-stimulated lipase; BSSL; Bucelipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase

products gene name :

CEL

products gene name syn :

CEL; BAL

other gene names :

CEL; CEL; BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8; BAL; BAL; BSSL

uniprot entry name :

CEL_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

21-753

sequence length :

733

sequence :

AKLGAVYTEG GFVEGVNKKL GLLGDSVDIF KGIPFAAPTK ALENPQPHPG WQGTLKAKNF KKRCLQATIT QDSTYGDEDC LYLNIWVPQG RKQVSRDLPV MIWIYGGAFL MGSGHGANFL NNYLYDGEEI ATRGNVIVVT FNYRVGPLGF LSTGDANLPG NYGLRDQHMA IAWVKRNIAA FGGDPNNITL FGESAGGASV SLQTLSPYNK GLIRRAISQS GVALSPWVIQ KNPLFWAKKV AEKVGCPVGD AARMAQCLKV TDPRALTLAY KVPLAGLEYP MLHYVGFVPV IDGDFIPADP INLYANAADI DYIAGTNNMD GHIFASIDMP AINKGNKKVT EEDFYKLVSE FTITKGLRGA KTTFDVYTES WAQDPSQENK KKTVVDFETD VLFLVPTEIA LAQHRANAKS AKTYAYLFSH PSRMPVYPKW VGADHADDIQ YVFGKPFATP TGYRPQDRTV SKAMIAYWTN FAKTGDPNMG DSAVPTHWEP YTTENSGYLE ITKKMGSSSM KRSLRTNFLR YWTLTYLALP TVTDQEATPV PPTGDSEATP VPPTGDSETA PVPPTGDSGA PPVPPTGDSG APPVPPTGDS GAPPVPPTGD SGAPPVPPTG DSGAPPVPPT GDSGAPPVPP TGDSGAPPVP PTGDSGAPPV PPTGDAGPPP VPPTGDSGAP PVPPTGDSGA PPVTPTGDSE TAPVPPTGDS GAPPVPPTGD SEAAPVPPTD DSKEAQMPAV IRF

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.

ncbi gi num :

251757481

ncbi acc num :

P19835.3

uniprot acc num :

P19835

ncbi mol weight :

96kD

ncbi pathways :

Acylglycerol Degradation Pathway (413388); Acylglycerol Degradation Pathway (468272); Digestion Of Dietary Lipid Pathway (106112); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolic Pathways (132956); Metabolism Pathway (477135)

ncbi summary :

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

uniprot summary :

CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; EC 3.1.1.3; Lipase; Lipid Metabolism - glycerolipid; EC 3.1.1.13; Lipid Metabolism - steroid biosynthesis. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: sterol esterase activity; heparin binding; triacylglycerol lipase activity; protein binding; hydrolase activity; acylglycerol lipase activity; catalytic activity. Biological Process: intestinal lipid catabolic process; triacylglycerol metabolic process; cholesterol absorption; lipid metabolic process; fatty acid catabolic process; pancreatic juice secretion; cholesterol catabolic process; protein amino acid esterification; lipid digestion. Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction

size1 :

0.5 mg (E-Coli)

price1 :

1545 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1545

size3 :

0.5 mg (Yeast)

price3 :

1770

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1770

size5 :

1 mg (E-Coli)

price5 :

2655

more info or order :

MyBioSource product webpage