Monkey Glucose-6-Phosphatase, Catalytic ELISA Kit | MyBioSource MBS096394 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Monkey Glucose-6-Phosphatase, Catalytic ELISA Kit

catalog :

MBS096394

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS096394

products type :

ELISA Kit

products full name :

Monkey Glucose-6-Phosphatase, Catalytic ELISA Kit

products short name :

[Glucose-6-Phosphatase, Catalytic]

other names :

[Glucose-6-phosphatase; Glucose-6-phosphatase; glucose-6-phosphatase; G6Pase; G-6-Pase; G6Pase-alpha; glucose-6-phosphatase alpha; glucose-6-phosphatase, catalytic subunit; Glucose-6-phosphatase alpha]

products gene name :

[G6PC]

other gene names :

[G6PC; G6PC; G6PT; GSD1; G6PC1; GSD1a; G6PT; G-6-Pase; G6Pase]

uniprot entry name :

G6PC_HUMAN

reactivity :

Monkey

sequence length :

357

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 3.12 U/L - 100 U/L. Sensitivity: 1.0 U/L.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of G6PC (hereafter termed this analyte) in undiluted original Monkey serum, plasma and tissue homogenate samples.

ncbi gi num :

206729864

ncbi acc num :

P35575.2

uniprot acc num :

P35575

ncbi mol weight :

40,484 Da

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); DNA Damage Response (only ATM Dependent) Pathway (198827); Disease Pathway (530764); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); FoxO Family Signaling Pathway (138036)

ncbi summary :

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]

uniprot summary :

G6PC: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A). A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Belongs to the glucose-6-phosphatase family. Protein type: Carbohydrate Metabolism - galactose; Endoplasmic reticulum; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); Carbohydrate Metabolism - starch and sucrose; EC 3.1.3.9. Chromosomal Location of Human Ortholog: 17q21. Cellular Component: endoplasmic reticulum membrane; integral to membrane; integral to endoplasmic reticulum membrane. Molecular Function: glucose-6-phosphatase activity; phosphotransferase activity, alcohol group as acceptor; phosphate binding. Biological Process: glycogen metabolic process; response to food; steroid metabolic process; phosphorylated carbohydrate dephosphorylation; glycogen catabolic process; multicellular organism growth; glucose 6-phosphate metabolic process; pathogenesis; glucose transport; glucose homeostasis; gluconeogenesis; cholesterol homeostasis; triacylglycerol metabolic process; urate metabolic process; regulation of gene expression; glucose-6-phosphate transport; hexose transport; carbohydrate metabolic process; transmembrane transport. Disease: Glycogen Storage Disease Ia

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage