Human Complement Component 4a ELISA Kit | MyBioSource MBS093838 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Complement Component 4a ELISA Kit

catalog :

MBS093838

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS093838

products type :

ELISA Kit

products full name :

Human Complement Component 4a ELISA Kit

products short name :

[Complement Component 4a]

other names :

[complement C4-A isoform 1 preproprotein; Complement C4-A; complement C4-A; acidic C4; C4A anaphylatoxin; Rodgers form of C4; acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; complement component 4A (Rodgers blood group); Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2]

products gene name :

[C4a]

other gene names :

[C4A; C4A; C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2; CO4; CPAMD2]

uniprot entry name :

CO4A_HUMAN

reactivity :

Human

sequence length :

1744

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25 ug/ml - 8 ug/ml. Sensitivity: 0.1 ug/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of C4A (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

ncbi gi num :

67190748

ncbi acc num :

NP_009224.2

ncbi gb acc num :

NM_007293.2

uniprot acc num :

P0C0L4

ncbi mol weight :

192,785 Da

ncbi pathways :

Activation Of C3 And C5 Pathway (106412); Allograft Rejection Pathway (920963); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Pertussis Pathway (218111)

ncbi summary :

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

uniprot summary :

C4A: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway. Defects in C4A are the cause of complement component 4A deficiency (C4AD). A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus with or without associated glomerulonephritis. Defects in C4A are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Interindividual copy- number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE. Protein type: Inhibitor; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: extracellular region; plasma membrane. Molecular Function: complement component C1q binding; endopeptidase inhibitor activity. Biological Process: regulation of complement activation; innate immune response; inflammatory response; complement activation, classical pathway; complement activation. Disease: Complement Component 4a Deficiency; Blood Group, Chido/rodgers System

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095