catalog number :
MBS090030
products type :
ELISA Kit
products full name :
Pigeon Prostacyclin ELISA Kit
products short name :
Prostacyclin
other names :
prostacyclin receptor; Prostacyclin receptor; prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor; prostaglandin I2 (prostacyclin) receptor (IP); Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor
products gene name :
PGI2
other gene names :
PTGIR; PTGIR; IP; PRIPR; PRIPR; PGI receptor
uniprot entry name :
PI2R_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_000951.1
ncbi gb acc num :
NM_000960.3
ncbi mol weight :
40,956 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Eicosanoid Ligand-binding Receptors Pathway (106370); Endothelin Pathway (672453); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Hemostasis Pathway (106028); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)
ncbi summary :
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
uniprot summary :
PTGIR: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: integral to plasma membrane; plasma membrane; cytosol. Molecular Function: G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity. Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; negative regulation of smooth muscle cell proliferation; positive regulation of cAMP biosynthetic process; response to lipopolysaccharide; blood coagulation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of GTPase activity