Human Myosin Heavy Chain 8, Skeletal Muscle, Perinatal ELISA Kit | MyBioSource MBS088982 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Myosin Heavy Chain 8, Skeletal Muscle, Perinatal ELISA Kit

catalog :

MBS088982

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS088982

products type :

ELISA Kit

products full name :

Human Myosin Heavy Chain 8, Skeletal Muscle, Perinatal ELISA Kit

products short name :

[Myosin Heavy Chain 8, Skeletal Muscle, Perinatal]

other names :

[myosin-8; Myosin-8; myosin-8; myHC-perinatal; myosin heavy chain 8; fetal-myosin heavy chain; myosin heavy chain, skeletal muscle, perinatal; myosin, heavy polypeptide 8, skeletal muscle, perinatal; myosin, heavy chain 8, skeletal muscle, perinatal; Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal]

products gene name :

[MYH8]

other gene names :

[MYH8; MYH8; MyHC-pn; gtMHC-F; MyHC-peri; MyHC-perinatal]

uniprot entry name :

MYH8_HUMAN

reactivity :

Human

sequence length :

1937

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MYH8 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

153945790

ncbi acc num :

NP_002463.2

ncbi gb acc num :

NM_002472.2

uniprot acc num :

P13535

ncbi mol weight :

222,763 Da

ncbi pathways :

Membrane Trafficking Pathway (106160); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262); Tight Junction Pathway (83071); Tight Junction Pathway (482); Translocation Of GLUT4 To The Plasma Membrane Pathway (685554)

ncbi summary :

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]

uniprot summary :

MYH8: Muscle contraction. Defects in MYH8 are a cause of Carney complex variant (CACOV). Carney complex is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Familial cardiac myxomas are associated with spotty pigmentation of the skin and other phenotypes, including primary pigmented nodular adrenocortical dysplasia, extracardiac (frequently cutaneous) myxomas, schwannomas, and pituitary, thyroid, testicular, bone, ovarian, and breast tumors. Cardiac myxomas do not develop in all patients with the Carney complex, but affected patients have at least two features of the complex or one feature and a clinically significant family history. Defects in MYH8 are a cause of distal arthrogryposis type (DA7). A hereditary distal arthrogryposis characterized by an inability to open the mouth fully (trismus) and pseudocamptodactyly in which wrist dorsiflexion, but not volarflexion, produces involuntary flexion contracture of distal and proximal interphalangeal joints. Such hand and jaw contractures are caused by shortened flexor muscle-tendon units. Similar lower-limb contractures also produce foot deformity. The trismus-pseudocamptodactyly syndrome is a morbid autosomal dominant trait with variable expressivity but high penetrance. In these patients, trismus complicates dental care, feeding during infancy, and intubation for anesthesia, and the pseudocamptodactyly impairs manual dexterity, with consequent occupational and social disability. Many patients require surgical correction of contractures. Protein type: Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: sarcomere; cytoplasm; muscle myosin complex; cytosol. Molecular Function: microfilament motor activity; actin filament binding; calmodulin binding; structural constituent of muscle; ATPase activity; myosin light chain binding; ATP binding. Biological Process: skeletal muscle contraction; muscle contraction; metabolic process; muscle filament sliding. Disease: Carney Complex Variant; Arthrogryposis, Distal, Type 7

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage