catalog number :
MBS086990
products type :
ELISA Kit
products full name :
Monkey Interleukin 28B ELISA Kit
products short name :
[Interleukin 28B]
other names :
[interferon lambda-3; Interferon lambda-3; interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3); interferon, lambda 3; Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C]
products gene name :
[IL28B]
other gene names :
[IFNL3; IFNL3; IL28B; IL28C; IL-28B; IL28B; IL28C; ZCYTO22; IFN-lambda-3; IL-28B; IL-28C]
uniprot entry name :
IFNL3_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_742151.2
ncbi gb acc num :
NM_172139.2
ncbi mol weight :
21,706 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Type III Interferon Signaling Pathway (755437)
ncbi summary :
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
uniprot summary :
IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19q13.13. Cellular Component: extracellular space. Molecular Function: cytokine activity. Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus. Disease: Hepatitis C Virus, Susceptibility To
size4 :
10x96-Strip-Wells