catalog number :
MBS085684
products type :
ELISA Kit
products full name :
Human N-Acetyltransferase 8 Like Protein ELISA Kit
products short name :
[N-Acetyltransferase 8 Like Protein]
other names :
[N-acetylaspartate synthetase; N-acetylaspartate synthetase; N-acetylaspartate synthetase; NAA synthetase; camello-like protein 3; N-acetyltransferase 8-like (GCN5-related, putative); Camello-like protein 3; N-acetyltransferase 8-like protein]
products gene name :
[NAT8L]
other gene names :
[NAT8L; NAT8L; CML3; NACED; NAT8-LIKE; CML3; NAA synthetase]
uniprot entry name :
NAT8L_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NAT8L (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.
ncbi mol weight :
32,837 Da
ncbi pathways :
Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Metapathway Biotransformation (198837)
ncbi summary :
This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]
uniprot summary :
NAT8L: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED). A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Belongs to the camello family. Protein type: Acetyltransferase; EC 2.3.1.17; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: mitochondrion; cytoplasm; mitochondrial membrane; integral to membrane; rough endoplasmic reticulum membrane. Molecular Function: aspartate N-acetyltransferase activity. Biological Process: positive regulation of dopamine uptake; metabolic process. Disease: N-acetylaspartate Deficiency
size4 :
10x96-Strip-Wells