ELISA/assay

Cat Retinol Binding Protein ELISA Kit

MBS085329

48-Strip-Wells

470 USD

ELISA Kit

Cat Retinol Binding Protein ELISA Kit

[Retinol Binding Protein]

[retinol-binding protein; Retinol-binding protein 3; retinol-binding protein 3; interphotoreceptor retinoid-binding protein; retinol binding protein 3, interstitial; Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein]

[RBP]

[RBP3; RBP3; IRBP; RBPI; RP66; D10S64; D10S65; D10S66; IRBP]

RET3_HUMAN

Cat

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 6.25 ug/ml - 200 ug/ml. Sensitivity: 1.0 ug/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of RBP (hereafter termed "analyte") in undiluted original Cat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

307075

AAA59188.1

P10745

135,363 Da

Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Signal Transduction Pathway (477114); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (771585); The Retinoid Cycle In Cones (daylight Vision) Pathway (771586); Visual Phototransduction Pathway (771584); The Visual Cycle I (vertebrates) Pathway (545451); The Visual Cycle I (vertebrates) Pathway (545294)

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]

RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: extracellular space; extracellular region; vesicle. Molecular Function: retinoid binding; serine-type peptidase activity; retinal binding; retinol binding. Biological Process: phototransduction, visible light; visual perception; transport; lipid metabolic process; proteolysis; retinoid metabolic process. Disease: Retinitis Pigmentosa 66; Retinitis Pigmentosa

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095