Mouse Notch Homolog 2 ELISA Kit | MyBioSource MBS081588 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Notch Homolog 2 ELISA Kit

catalog :

MBS081588

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS081588

products type :

ELISA Kit

products full name :

Mouse Notch Homolog 2 ELISA Kit

products short name :

[Notch Homolog 2]

other names :

[neurogenic locus notch homolog protein 2 isoform 1 preproprotein; Neurogenic locus notch homolog protein 2; neurogenic locus notch homolog protein 2; Notch homolog 2; notch 2]

products gene name :

[NOTCH2]

other gene names :

[NOTCH2; NOTCH2; hN2; AGS2; HJCYS; Notch 2; hN2]

uniprot entry name :

NOTC2_HUMAN

reactivity :

Mouse

sequence length :

2471

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NOTCH2 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

24041035

ncbi acc num :

NP_077719.2

ncbi gb acc num :

NM_024408.3

uniprot acc num :

Q04721

ncbi mol weight :

265,405 Da

ncbi pathways :

Delta-Notch Signaling Pathway (198879); Dorso-ventral Axis Formation Pathway (114227); Dorso-ventral Axis Formation Pathway (472); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway (771602); NOTCH2 Intracellular Domain Regulates Transcription Pathway (833830); Neural Crest Differentiation Pathway (672460)

ncbi summary :

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1p13-p11. Cellular Component: Golgi membrane; nucleoplasm; endoplasmic reticulum membrane; cell surface; membrane; integral to plasma membrane; extracellular region; plasma membrane; nucleus; receptor complex; cilium. Molecular Function: protein binding; receptor activity; calcium ion binding. Biological Process: apoptosis; positive regulation of apoptosis; multicellular organismal development; myeloid dendritic cell differentiation; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelial sheet; hemopoiesis; cell cycle arrest; cell growth; positive regulation of BMP signaling pathway; embryonic limb morphogenesis; nervous system development; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; intracellular receptor-mediated signaling pathway; in utero embryonic development; stem cell maintenance; Notch receptor processing; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; defense response to bacterium; gene expression; positive regulation of Ras protein signal transduction; determination of left/right symmetry; negative regulation of apoptosis. Disease: Hajdu-cheney Syndrome; Alagille Syndrome 2

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095