Rat Ryanodine Receptor 2, Cardiac ELISA Kit | MyBioSource MBS080022 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Ryanodine Receptor 2, Cardiac ELISA Kit

catalog :

MBS080022

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS080022

products type :

ELISA Kit

products full name :

Rat Ryanodine Receptor 2, Cardiac ELISA Kit

products short name :

Ryanodine Receptor 2, Cardiac

other names :

ryanodine receptor 2; Ryanodine receptor 2; ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; ryanodine receptor 2 (cardiac); Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor

products gene name :

RYR2

other gene names :

RYR2; RYR2; RyR; ARVC2; ARVD2; RYR-2; VTSIP; RYR-2; RyR2; hRYR-2

uniprot entry name :

RYR2_HUMAN

reactivity :

Rat

sequence length :

4967

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 31.2 pg/ml -1000 pg/ml. Sensitivity: 5.0 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of RYR2 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

112799847

ncbi acc num :

NP_001026.2

ncbi gb acc num :

NM_001035.2

uniprot acc num :

Q92736

ncbi mol weight :

564,567 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992)

ncbi summary :

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

uniprot summary :

RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Channel, ligand-gated; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q43. Cellular Component: sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; sarcoplasmic reticulum; membrane; plasma membrane; Z disc. Molecular Function: calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity. Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; BMP signaling pathway; cellular calcium ion homeostasis; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction. Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage