Canine Calcium/Calmodulin Dependent Protein Kinase II Alpha ELISA Kit | MyBioSource MBS076061 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Canine Calcium/Calmodulin Dependent Protein Kinase II Alpha ELISA Kit

catalog :

MBS076061

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS076061

products type :

ELISA Kit

products full name :

Canine Calcium/Calmodulin Dependent Protein Kinase II Alpha ELISA Kit

products short name :

[Calcium/Calmodulin Dependent Protein Kinase II Alpha]

other names :

[calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2; Calcium/calmodulin-dependent protein kinase type II subunit alpha; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha]

products gene name :

[CAMK2alpha]

other gene names :

[CAMK2A; CAMK2A; CAMKA; CAMKA; KIAA0968; CaM kinase II subunit alpha]

uniprot entry name :

KCC2A_HUMAN

reactivity :

Canine

sequence length :

478

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CAMK2A (hereafter termed "analyte") in undiluted original Canine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

25952118

ncbi acc num :

NP_741960.1

ncbi gb acc num :

NM_171825.2

uniprot acc num :

Q9UQM7

ncbi mol weight :

54,088 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); BDNF Signaling Pathway (712093); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Ca2+ Pathway (941399); Calcium Regulation In The Cardiac Cell Pathway (198906)

ncbi summary :

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

uniprot summary :

CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; EC 2.7.11.17; CAMK group; CAMK2 family. Chromosomal Location of Human Ortholog: 5q32. Cellular Component: presynaptic membrane; nucleoplasm; mitochondrion; plasma membrane; nucleus; cell junction; cytosol. Molecular Function: calmodulin binding; protein serine/threonine kinase activity; glutamate receptor binding; protein binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; kinase activity; ATP binding. Biological Process: synaptic transmission; peptidyl-serine phosphorylation; calcium ion transport; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; regulation of neurotransmitter secretion; positive regulation of calcium ion transport; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; regulation of neuronal synaptic plasticity; G1/S transition of mitotic cell cycle

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage