Fish Tight Junction Protein 2 ELISA Kit | MyBioSource MBS074295 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Fish Tight Junction Protein 2 ELISA Kit

catalog :

MBS074295

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS074295

products type :

ELISA Kit

products full name :

Fish Tight Junction Protein 2 ELISA Kit

products short name :

[Tight Junction Protein 2]

other names :

[tight junction protein ZO-2 isoform 2; Tight junction protein ZO-2; tight junction protein ZO-2; zona occludens 2; zonula occludens protein 2; Friedreich ataxia region gene X104 (tight junction protein ZO-2); tight junction protein 2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2]

products gene name :

[TJP2]

other gene names :

[TJP2; TJP2; ZO2; X104; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11; X104; ZO2]

uniprot entry name :

ZO2_HUMAN

reactivity :

Fish

sequence length :

1043

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Horse Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of TJP1 (hereafter termed "analyte") in undiluted original Horse serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

ncbi gi num :

42518065

ncbi acc num :

NP_963923.1

ncbi gb acc num :

NM_201629.3

uniprot acc num :

Q9UDY2

ncbi mol weight :

133,958 Da

ncbi pathways :

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Signal Transduction Pathway (477114); Signaling By Hippo Pathway (576275); Tight Junction Pathway (83071); Tight Junction Pathway (482); Validated Targets Of C-MYC Transcriptional Repression Pathway (169353); Vibrio Cholerae Infection Pathway (83101)

ncbi summary :

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

uniprot summary :

ZO2: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 9q13-q21. Cellular Component: nucleoplasm; tight junction; adherens junction; cytoplasm; plasma membrane; cytosol; cell junction. Molecular Function: protein C-terminus binding; protein binding, bridging; guanylate kinase activity; protein domain specific binding; protein binding. Biological Process: response to organic substance; apoptosis; intestinal absorption; cell structure disassembly during apoptosis; nucleotide phosphorylation. Disease: Hypercholanemia, Familial; Cholestasis, Progressive Familial Intrahepatic, 4

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095