catalog number :
MBS060213
products type :
ELISA Kit
products full name :
Fish A Disintegrin and Metalloprotease 11 ELISA Kit
products short name :
A Disintegrin and Metalloprotease 11
other names :
A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM metallopeptidase with thrombospondin type 1 motif, 5; A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2
products gene name :
ADAM11
other gene names :
ADAMTS5; ADAMTS5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11; ADAMTS11; ADMP2; ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADAM-TS 11; ADAMTS-11
uniprot entry name :
ATS5_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi mol weight :
101,718 Da
ncbi pathways :
Degradation Of The Extracellular Matrix Pathway (576263); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Metabolism Of Proteins Pathway (106230); O-glycosylation Of TSR Domain-containing Proteins Pathway (980460); O-linked Glycosylation Pathway (980459); Post-translational Protein Modification Pathway (161012)
ncbi summary :
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
uniprot summary :
ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. Protein type: Motility/polarity/chemotaxis; Secreted; Protease; Extracellular matrix; EC 3.4.24.-; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 21q21.3. Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region. Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity. Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; post-translational protein modification; proteolysis