ELISA/assay

Human Frizzled Related Protein ELISA Kit

MBS058501

48-Strip-Wells

470 USD

ELISA Kit

Human Frizzled Related Protein ELISA Kit

[Frizzled Related Protein]

[Frzb; Secreted frizzled-related protein 3; secreted frizzled-related protein 3; sFRP-3; frezzled; frizzled homolog-related; frizzled-related protein 1; frizzled-related protein; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1]

[FRZB]

[FRZB; FRZB; FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN; FIZ; FRE; FRP; FRZB1; SFRP3; sFRP-3]

SFRP3_HUMAN

Human

325

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SFRP3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

1620541

AAC50736.1

Q92765

36,254 Da

Adipogenesis Pathway (198832); Endochondral Ossification Pathway (198812)

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q32.1. Cellular Component: extracellular space; membrane; integral to membrane. Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity. Biological Process: negative regulation of cell proliferation; convergent extension involved in organogenesis; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; positive regulation of fat cell differentiation; neural crest cell differentiation; negative regulation of cell growth; skeletal development. Disease: Osteoarthritis Susceptibility 1

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095