catalog number :
MBS046928
products type :
ELISA Kit
products full name :
Canine Interleukin 11 ELISA Kit
products short name :
[Interleukin 11]
other names :
[interleukin-11 isoform 2; Interleukin-11; interleukin-11; oprelvekin; adipogenesis inhibitory factor; interleukin 11; Adipogenesis inhibitory factor]
products gene name :
[IL-11]
other gene names :
[IL11; IL11; AGIF; IL-11; IL-11; AGIF]
uniprot entry name :
IL11_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 6.25 pg/ml - 200 pg/ml. Sensitivity: 1.0 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of IL-11 (hereafter termed this analyte) in Canine serum, plasma and tissue homogenate samples.
ncbi acc num :
NP_001254647.1
ncbi gb acc num :
NM_001267718.1
ncbi mol weight :
21,429 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Integrated Pancreatic Cancer Pathway (711360); Interleukin-11 Signaling Pathway (698753); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269)
ncbi summary :
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
uniprot summary :
IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily. Protein type: Secreted, signal peptide; Cell cycle regulation; Motility/polarity/chemotaxis; Cytokine. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: growth factor activity; cytokine activity; interleukin-11 receptor binding. Biological Process: fat cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; cell-cell signaling; megakaryocyte differentiation; B cell differentiation; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation
size4 :
10x96-Strip-Wells