catalog number :
MBS045980
products type :
ELISA Kit
products full name :
Chicken Catalase ELISA Kit
products short name :
Catalase
other names :
catalase; Catalase; catalase; catalase
other gene names :
CAT; CAT
uniprot entry name :
CATA_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_001743.1
ncbi gb acc num :
NM_001752.3
ncbi mol weight :
59,756 Da
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!DNA Damage Response (only ATM Dependent) Pathway 198827!!Folate Metabolism Pathway 198833!!FoxO Family Signaling Pathway 138036!!Glyoxylate And Dicarboxylate Metabolism Pathway 83002!!Glyoxylate And Dicarboxylate Metabolism Pathway 383!!Metabolism Pathway 477135!!Metabolism Of Nucleotides Pathway 106263!!Oxidative Stress Pathway 198916
ncbi summary :
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
uniprot summary :
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Ref.11. Catalytic activity: 2 H2O2 = O2 + 2 H2O. Ref.11. Cofactor: Heme group.NADP. Subunit structure: Homotetramer. Subcellular location: Peroxisome. Post-translational modification: The N-terminus is blocked. Involvement in disease: Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14. Sequence similarities: Belongs to the catalase family.