ELISA/assay

Rat Angiopoietin 1 ELISA Kit

MBS045817

96 Strip Wells

600 USD

ELISA Kit

Rat Angiopoietin 1 ELISA Kit

Angiopoietin 1

angiopoietin-1 isoform 2; Angiopoietin-1; angiopoietin-1; ANG-1; angiopoietin 1

ANG1

ANGPT1; ANGPT1; AGP1; AGPT; ANG1; KIAA0003; ANG-1

ANGP1_HUMAN

Rat

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

315434240

NP_001186788.1

NM_001199859.1

Q15389

57,513 Da

Angiogenesis Pathway 198772!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!HIF-1 Signaling Pathway 695200!!Hemostasis Pathway 106028!!PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979!!Rheumatoid Arthritis Pathway 200309!!Rheumatoid Arthritis Pathway 200269!!Tie2 Signaling Pathway 106063

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Ref.10 Ref.12 Ref.13 Ref.14. Subunit structure: Homooligomer. Interacts with TEK/TIE2. Ref.10 Ref.11 Ref.12. Subcellular location: Secreted. Post-translational modification: Glycosylated. Miscellaneous: It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart. Sequence similarities: Contains 1 fibrinogen C-terminal domain. Sequence caution: The sequence BAA02793.2 differs from that shown. Reason: Erroneous initiation.

96 Strip Wells

600 USD