ELISA/assay

Mouse Hedgehog Interacting Protein ELISA Kit

MBS045618

48-Strip-Wells

435 USD

ELISA Kit

Mouse Hedgehog Interacting Protein ELISA Kit

Hedgehog Interacting Protein

hedgehog-interacting protein; Hedgehog-interacting protein; hedgehog-interacting protein; hedgehog interacting protein

HHIP

HHIP; HHIP; HIP; HIP; HHIP; HIP

HHIP_HUMAN

Mouse

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HHIP (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

20143973

NP_071920.1

NM_022475.2

Q96QV1

78,851 Da

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Hedgehog Signaling Pathway (198835); Hedgehog Signaling Pathway (83063); Hedgehog Signaling Pathway (474); Pathways In Cancer (83105); Signaling Events Mediated By The Hedgehog Family Pathway (137950)

This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]

HHIP: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Belongs to the HHIP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell development/differentiation. Chromosomal Location of Human Ortholog: 4q28-q32. Cellular Component: cell surface; integral to plasma membrane; cytoplasm; extracellular region. Molecular Function: protein binding; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; zinc ion binding; quinone binding. Biological Process: smoothened signaling pathway; dorsal/ventral pattern formation; skeletal morphogenesis; negative regulation of smoothened signaling pathway; neuroblast proliferation; carbohydrate metabolic process; regulation of fibroblast growth factor receptor signaling pathway; negative regulation of signal transduction

48-Strip-Wells

435 USD

96-Strip-Wells

600