catalog number :
MBS044687
products type :
ELISA Kit
products full name :
Mouse Vascular Endothelial Growth Factor D ELISA Kit
products short name :
Vascular Endothelial Growth Factor D
other names :
vascular endothelial growth factor D preproprotein; Vascular endothelial growth factor D; vascular endothelial growth factor D; c-fos induced growth factor (vascular endothelial growth factor D); c-Fos-induced growth factor
products gene name :
VEGF-D
other gene names :
FIGF; FIGF; VEGFD; VEGF-D; VEGFD; VEGF-D; FIGF
uniprot entry name :
VEGFD_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich
ncbi acc num :
NP_004460.1
ncbi gb acc num :
NM_004469.4
ncbi mol weight :
40,444 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Hemostasis Pathway (106028); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105); Platelet Activation, Signaling And Aggregation Pathway (106034)
ncbi summary :
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
uniprot summary :
VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family. Protein type: Secreted; Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xp22.31. Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding; chemoattractant activity. Biological Process: platelet activation; cell proliferation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation; blood coagulation; induction of positive chemotaxis