ELISA/assay

Mouse Complement Factor I ELISA Kit

MBS043388

48-Strip-Wells

470 USD

ELISA Kit

Mouse Complement Factor I ELISA Kit

[Complement Factor I]

[complement factor I; Complement factor I; complement factor I; C3B/C4B inactivator; complement factor I; C3B/C4B inactivator]

[CFI]

[Cfi; Cfi; If]

CFAI_RAT

Mouse

No significant cross-reactivity or interference between Mouse CFI and analogues was observed.

Store all reagents at 2-8 degree C

Samples: Human Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 6.25ng/ml-200ng/ml. Sensitivity: 1.0ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of CFHR3 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

13162353

NP_077071.1

NM_024157.1

Q9WUW3

67,298 Da

Complement And Coagulation Cascades Pathway (198461); Complement And Coagulation Cascades Pathway (83465); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (829106); Immune System Pathway (829042); Innate Immune System Pathway (829071); Regulation Of Complement Cascade Pathway (829114); Staphylococcus Aureus Infection Pathway (172815); Staphylococcus Aureus Infection Pathway (171867)

mouse homolog is a regulatory serine proteinase of the complement cascade that cleaves C3b and C4b and inactivates them [RGD, Feb 2006]

CFI: Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Defects in CFI are the cause of complement factor I deficiency (CFI deficiency). CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections. Belongs to the peptidase S1 family. Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.45; Protease. Cellular Component: extracellular space; membrane; nucleus. Molecular Function: metal ion binding; serine-type endopeptidase activity; scavenger receptor activity. Biological Process: receptor-mediated endocytosis; innate immune response; proteolysis; complement activation, classical pathway

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095