ELISA/assay

Human Glycoprotein VI, Platelet ELISA Kit

MBS042963

48-Strip-Wells

435 USD

ELISA Kit

Human Glycoprotein VI, Platelet ELISA Kit

Glycoprotein VI, Platelet

glycoprotein VI, partial; Platelet glycoprotein VI; platelet glycoprotein VI; glycoprotein 6; platelet collagen receptor; glycoprotein VI (platelet); Glycoprotein 6

GP6

GP6; GP6; GPIV; GPVI; BDPLT11; GPVI

GPVI_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GP6 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

26985217

AAN86273.1

Q9HCN6

36,866 Da

Cell Surface Interactions At The Vascular Wall Pathway (106062); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); GPVI-mediated Activation Cascade Pathway (106036); Hemostasis Pathway (106028); Platelet Adhesion To Exposed Collagen Pathway (106030); Platelet Activation, Signaling And Aggregation Pathway (106034)

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GPVI: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11). BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: collagen binding; protein binding; transmembrane receptor activity; receptor activity. Biological Process: platelet activation; blood coagulation; leukocyte migration; enzyme linked receptor protein signaling pathway. Disease: Bleeding Disorder, Platelet-type, 11

48-Strip-Wells

435 USD

96-Strip-Wells

600