ELISA/assay

Monkey Coagulation Factor VIII ELISA Kit

MBS041116

48-Strip-Wells

470 USD

ELISA Kit

Monkey Coagulation Factor VIII ELISA Kit

[Coagulation Factor VIII]

[coagulation factor VIII isoform 1; Coagulation factor VIII; coagulation factor VIII; Factor VIII; procoagulant component; coagulation factor VIII; Procoagulant component]

[F8]

[F8; F8; Cf8; Cf-8; FVIII; Cf8; F8c]

FA8_MOUSE

Monkey

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 15.6 ug/ml - 500 ug/ml. Sensitivity: 2.0 ug/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of F8 (hereafter termed "analyte") in undiluted original Monkey body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

238624180

NP_032003.2

NM_007977.2

Q06194

266,196 Da

Blood Clotting Cascade Pathway (198388); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (819729); Hemostasis Pathway (819701); Intrinsic Pathway (819731); Platelet Activation, Signaling And Aggregation Pathway (819711); Platelet Degranulation Pathway (819728); Response To Elevated Platelet Cytosolic Ca2+ Pathway (819726)

F8: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Defects in F8 are the cause of hemophilia A (HEMA). A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non- functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Cellular Component: extracellular space; extracellular region. Molecular Function: copper ion binding; metal ion binding; serine-type endopeptidase activity; oxidoreductase activity. Biological Process: platelet activation; hemostasis; acute-phase response; proteolysis; blood coagulation; blood coagulation, intrinsic pathway

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095