catalog number :
MBS040547
products type :
ELISA Kit
products full name :
Cavy Cotinine ELISA Kit
products short name :
[Cotinine]
other names :
[claudin-14; Claudin-14; claudin-14; claudin 14]
products gene name :
[COTININE]
other gene names :
[CLDN14; CLDN14; DFNB29]
uniprot entry name :
CLD14_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Cavy body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CTN (hereafter termed "analyte") in undiluted original Cavy body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001139550.1
ncbi gb acc num :
NM_001146078.2
ncbi mol weight :
25,699 Da
ncbi pathways :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Tight Junction Pathway (83071)
ncbi summary :
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
uniprot summary :
Claudin-14: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family. Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: tight junction; endoplasmic reticulum; integral to membrane; plasma membrane. Molecular Function: identical protein binding; structural molecule activity. Biological Process: intercellular junction assembly and maintenance; protein complex assembly; calcium-independent cell-cell adhesion. Disease: Deafness, Autosomal Recessive 29
size4 :
10x96-Strip-Wells