catalog number :
MBS040508
products type :
ELISA Kit
products full name :
Mouse Eosinophil Cationic Protein ELISA Kit
products short name :
Eosinophil Cationic Protein
other names :
eosinophil cationic protein; Eosinophil cationic protein; eosinophil cationic protein; RNase 3; ribonuclease 3; cytotoxic ribonuclease; ribonuclease, RNase A family, 3; Ribonuclease 3
other gene names :
RNASE3; RNASE3; ECP; RNS3; ECP; RNS3; ECP; RNase 3
uniprot entry name :
ECP_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_002926.2
ncbi gb acc num :
NM_002935.2
ncbi mol weight :
18,385 Da
ncbi pathways :
Asthma Pathway 83120!!Asthma Pathway 532
uniprot summary :
Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Ref.10 Ref.12. Subunit structure: Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7. Ref.12. Subcellular location: Secreted. Note: Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus. Sequence similarities: Belongs to the pancreatic ribonuclease family.