ELISA/assay

Rat Orexin A ELISA Kit

MBS040206

48-Strip-Wells

435 USD

ELISA Kit

Rat Orexin A ELISA Kit

Orexin A

orexin; Orexin; orexin; prepro-orexin; hypocretin (orexin) neuropeptide precursor; Hypocretin; HcrtCleaved into the following 2 chains:Orexin-A; Alternative name(s):; Hypocretin-1; Hcrt1Orexin-B; Alternative name(s):; Hypocretin-2

OX-A

HCRT; HCRT; OX; PPOX; NRCLP1; OX; PPORX; PPOX; Hcrt; Hcrt1; Hcrt2

OREX_HUMAN

Rat

131

Store all reagents at 2-8 degree C

Assay Type: Sandwich

4557635

NP_001515.1

NM_001524.1

O43612

13,363 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway (106362); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

HCRT: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1). Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Belongs to the orexin family. Protein type: Hormone. Chromosomal Location of Human Ortholog: 17q21. Cellular Component: synaptic vesicle; rough endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region; cell junction; secretory granule. Molecular Function: type 2 hypocretin receptor binding; type 1 hypocretin receptor binding. Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; negative regulation of DNA replication; eating behavior; neuropeptide signaling pathway; negative regulation of potassium ion transport; protein kinase C activation; regulation of neurotransmitter secretion; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; positive regulation of transmission of nerve impulse. Disease: Narcolepsy 1

48-Strip-Wells

435 USD

96-Strip-Wells

600