ELISA/assay

Human Deoxypyridinoline ELISA Kit

MBS039364

48-Strip-Wells

435 USD

ELISA Kit

Human Deoxypyridinoline ELISA Kit

Deoxypyridinoline

Dihydropyrimidine dehydrogenase

DPD

Human

1025

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 6.25 nmol/L - 200 nmol/L. Sensitivity: 1.0 nmol/L.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DPD (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

160332325

Q12882.2

Drug Metabolism - Other Enzymes Pathway (83033); Drug Metabolism - Other Enzymes Pathway (428); Fluoropyrimidine Activity Pathway (198778); Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Pantothenate And CoA Biosynthesis Pathway (83015); Pantothenate And CoA Biosynthesis Pathway (401); Pyrimidine Catabolism Pathway (106288); Pyrimidine Degradation, Uracil = Beta-alanine, Thymine = 3-aminoisobutanoate Pathway (605866); Pyrimidine Degradation, Uracil = Beta-alanine, Thymine = 3-aminoisobutanoate Pathway (468239)

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

DPYD: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Homodimer. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. Belongs to the dihydropyrimidine dehydrogenase family. Protein type: Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 1.3.1.2. Chromosomal Location of Human Ortholog: 1p22. Cellular Component: cytoplasm; cytosol. Molecular Function: protein homodimerization activity; FAD binding; metal ion binding; 4 iron, 4 sulfur cluster binding; dihydroorotate dehydrogenase activity; dihydropyrimidine dehydrogenase (NADP+) activity; NADP binding. Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; UMP biosynthetic process; uracil catabolic process; beta-alanine biosynthetic process; thymine catabolic process; purine base catabolic process; thymidine catabolic process; pyrimidine base catabolic process. Disease: Dihydropyrimidine Dehydrogenase Deficiency

48-Strip-Wells

435 USD

96-Strip-Wells

600