ELISA/assay

Human Lysyl Oxidase ELISA Kit

MBS039099

48-Strip-Wells

435 USD

ELISA Kit

Human Lysyl Oxidase ELISA Kit

Lysyl Oxidase

lysyl oxidase; Protein-lysine 6-oxidase; protein-lysine 6-oxidase; lysyl oxidase; Lysyl oxidase

LOX

LOX; LOX

LYOX_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of LOX (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

257065

AAB23549.1

P28300

46,944 Da

Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Formation Pathway (645288); Crosslinking Of Collagen Fibrils Pathway (730308); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262)

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. Protein type: Secreted; Oxidoreductase; EC 1.4.3.13; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q23.2. Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region; nucleus. Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity. Biological Process: response to drug; blood vessel development; elastic fiber assembly; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; response to steroid hormone stimulus; protein modification process; lung development. Disease: Cutis Laxa, Autosomal Recessive, Type Ia

48-Strip-Wells

435 USD

96-Strip-Wells

600