catalog number :
MBS038818
products type :
ELISA Kit
products full name :
Fish Catalase ELISA Kit
products short name :
[Catalase]
other names :
[catalase; Catalase; catalase; catalase]
products gene name :
[CAT]
other gene names :
[CAT; CAT]
uniprot entry name :
CATA_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Mouse Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%)is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of CASR (hereafter termed "analyte") in undiluted original Mouse body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001743.1
ncbi gb acc num :
NM_001752.3
ncbi mol weight :
59,756 Da
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); DNA Damage Response (only ATM Dependent) Pathway (198827); Folate Metabolism Pathway (198833); FoxO Family Signaling Pathway (138036); Glyoxylate And Dicarboxylate Metabolism Pathway (83002); Glyoxylate And Dicarboxylate Metabolism Pathway (383); Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Oxidative Stress Pathway (198916)
ncbi summary :
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
uniprot summary :
Catalase: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family. Protein type: Hydrolase; Energy Metabolism - methane; Apoptosis; EC 1.11.1.6; Amino Acid Metabolism - tryptophan; Oxidoreductase; Endoplasmic reticulum; Mitochondrial. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: Golgi apparatus; peroxisomal membrane; peroxisomal matrix; focal adhesion; membrane; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum; plasma membrane; mitochondrial intermembrane space; peroxisome; cytosol. Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; enzyme binding; catalase activity; metal ion binding; heme binding; NADP binding; aminoacylase activity; receptor binding. Biological Process: cholesterol metabolic process; nucleobase, nucleoside and nucleotide metabolic process; hemoglobin metabolic process; purine base metabolic process; activation of NF-kappaB transcription factor; protein homotetramerization; positive regulation of phosphoinositide 3-kinase cascade; osteoblast differentiation; response to reactive oxygen species; response to vitamin E; triacylglycerol metabolic process; response to hyperoxia; UV protection; inhibition of NF-kappaB transcription factor; hydrogen peroxide catabolic process; ureteric bud development; positive regulation of cell division; response to hypoxia; aerobic respiration; purine nucleotide catabolic process; protein tetramerization; negative regulation of apoptosis; aging. Disease: Acatalasemia
size4 :
10x96-Strip-Wells