Human Fibronection Related Antigen ELISA Kit | MyBioSource MBS038318 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Fibronection Related Antigen ELISA Kit

catalog :

MBS038318

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS038318

products type :

ELISA Kit

products full name :

Human Fibronection Related Antigen ELISA Kit

products short name :

Fibronection Related Antigen

other names :

fos-related antigen 1 isoform 2; Fos-related antigen 1; fos-related antigen 1; FOS-like antigen-1; FOS-like antigen 1

products gene name :

FRA

other gene names :

FOSL1; FOSL1; FRA; FRA1; fra-1; FRA1; FRA-1

uniprot entry name :

FOSL1_HUMAN

reactivity :

Human

sequence length :

235

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich

ncbi gi num :

664806071

ncbi acc num :

NP_001287773.1

ncbi gb acc num :

NM_001300844.1

uniprot acc num :

P15407

ncbi mol weight :

29,413 Da

ncbi pathways :

Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Corticotropin-releasing Hormone Pathway (920957); DNA Damage Response (only ATM Dependent) Pathway (198827); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Validated Targets Of C-MYC Transcriptional Activation Pathway (169351)

ncbi summary :

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

uniprot summary :

FRA1: an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA1 is involved in cell motility, invasiveness, and inhibits apoptosis. Elevated in many cancers and associated with tumorigenesis and cancer progression. Involved in Erk2-mediated Epithelial-to-Mesenchymal Transition (EMT) pathway. ERK2/FRA2 regulate ZEB1/2 expression, known to be associated with the EMT. Smad2/3-Fra1 complexes may reflect activation of the Smad/AP-1-dependent TGFÂ¿-induced breast cancer invasion program. Activation of FRA1/C-JUN by ERK/AKT pathways can induce EZH2 overexpression, silencing integrin alpha-2 expression, and increasing the metastatic potential of colorectal cancer. Belongs to the bZIP family. Fos subfamily. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: presynaptic membrane; nucleoplasm; neuron projection; cytosol; nucleus. Molecular Function: protein binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; response to drug; response to gravity; response to cAMP; positive regulation of apoptosis; in utero embryonic development; response to virus; vitellogenesis; positive regulation of cell cycle; learning; female pregnancy; chemotaxis; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; positive regulation of cell proliferation; cellular response to extracellular stimulus; cellular defense response; positive regulation of transcription factor activity; response to progesterone stimulus; response to corticosterone stimulus

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage